Vitamin B3 (Niacinamide) – 16mg (100%)
A water-soluble B-vitamin that functions as a precursor to NAD⁺, critical for cellular metabolism, energy production, and vascular support.
- Supports vasodilation and increased blood flow via improved endothelial function.
- Enhances mitochondrial efficiency and energy metabolism through NAD⁺ biosynthesis.
- Promotes neuroprotection and cellular repair.
- Helps regulate lipid metabolism and insulin sensitivity.
- Aids in reducing fatigue and enhancing endurance capacity.
Synergy: Pairs with Nitrosigine and VasoDrive AP to support vasodilation and performance blood flow.
- Knip M et al. Diabetologia. 2000;43(10):1223–1231.
- Revollo JR et al. J Biol Chem. 2004;279(49):50754–50763.
- Bogan KL, Brenner C. Annu Rev Nutr. 2008;28:115–130.
Potassium (from Nitrosigine®) – 60mg (2%)
An essential mineral and electrolyte critical for cellular hydration, muscle contractions, and cardiovascular function.
- Regulates fluid balance and intracellular hydration.
- Supports proper nerve signaling and muscle contraction.
- Aids in maintaining normal blood pressure and vascular tone.
- Enhances cardiovascular output during exercise.
- Reduces risk of exercise-related cramps and fatigue.
Synergy: Combines with arginine (from Nitrosigine) and Grape Seed Extract to support endothelial nitric oxide signaling and vasodilation.
- He FJ, MacGregor GA. Hypertension. 2008;51(4):848–855.
- Houston M. J Clin Hypertens. 2011;13(10):748–753.
- Palmer BF, Clegg DJ. Adv Physiol Educ. 2016;40(4):480–486.
Nitrosigine® (Inositol-Stabilized Arginine Silicate) – 1,500mg
A patented complex that enhances nitric oxide levels by improving arginine bioavailability and endothelial function.
- Increases nitric oxide (NO) for vasodilation and enhanced blood flow.
- Improves cognitive performance and mental focus.
- Enhances muscle pumps, oxygen delivery, and nutrient transport.
- Promotes endothelial integrity and vascular flexibility.
- Clinically shown to elevate arginine levels for up to 6 hours post-dose.
Synergy: Pairs with VasoDrive AP, Epimedium, and Grape Seed for amplified NO production and vascular performance.
- Kalman DS et al. Nutrients. 2015;7(7):5632–5643.
- Campbell B et al. J Int Soc Sports Nutr. 2016;13:26.
- Gonzalez AM et al. Nutrients. 2020;12(3):698.
Epimedium (Epimedium sagittatum) Extract (std. 20% Icariin) – 1,000mg
A traditional herbal adaptogen known for icariin content that enhances nitric oxide synthesis, blood flow, and libido.
- Stimulates eNOS (endothelial nitric oxide synthase) activity to boost vasodilation.
- Supports libido, testosterone signaling, and hormone balance.
- Demonstrates antioxidant and neuroprotective effects.
- Enhances endurance via mitochondrial stimulation.
- Promotes smooth muscle relaxation for vascular and sexual health.
Synergy: Stacks well with Nitrosigine, Grape Seed, and CitraPeak for NO and blood flow synergy.
- Xin ZC et al. Int J Impot Res. 2003;15(6):538–546.
- Dell’Agli M et al. Eur Urol. 2008;54(4):835–843.
- Pan Y et al. Andrologia. 2018;50(10):e13110.
VasoDrive AP® – 508mg
Bioactive tripeptides from casein protein that support vascular tone.
- Enhances blood flow and endothelial health by modulating ACE activity.
- Inhibits angiotensin-converting enzyme (ACE) for better blood vessel relaxation.
- Reduces systolic and diastolic blood pressure in healthy adults.
- Enhances vascular function and peripheral blood flow.
- Improves recovery through oxygen-rich circulation.
- May support heart rate variability and stress recovery.
Synergy: Combines with Nitrosigine, Epimedium, and CellFlo6 for NO-driven performance flow and cardiovascular support.
- Fekete AA et al. Nutrients. 2015;7(1):1–17.
- Jauhiainen & Korpela, British Journal of Nutrition, 2007
- Nakamura Y et al. J Nutr. 1995;125(4):829–834
- Seppo L et al. Am J Clin Nutr. 2003;77(2):326–330.
CellFlo6® Green Tea Extract (Camellia sinensis) – 300mg
A specialized green tea leaf extract rich in catechins and polyphenols for vascular, metabolic, and cognitive support.
- Enhances endothelial nitric oxide and capillary circulation.
- Supports metabolism and fat oxidation.
- Exhibits strong antioxidant effects in vascular tissues.
- Promotes mental focus and neurovascular perfusion.
- Helps buffer inflammation and oxidative stress from training.
Synergy: Stacks synergistically with Grape Seed, CitraPeak, and Nitrosigine for antioxidant-enhanced vasodilation.
- Kim W et al. J Med Food. 2013;16(4):346–351.
- Wang H et al. Free Radic Biol Med. 2004;36(4):552–559.
- Dulloo AG et al. Am J Clin Nutr. 1999;70(6):1040–1045.
Oleano 35® (Oleanolic Acid, std. min. 35%) from Olive Fruit – 250mg
A triterpenoid compound with anti-inflammatory and endothelial-supporting properties.
- Enhances nitric oxide signaling and arterial function.
- Exhibits strong antioxidant and anti-inflammatory properties.
- Supports vascular relaxation and capillary flexibility.
- May reduce oxidative damage to blood vessel linings.
- Promotes metabolic and lipid health.
Synergy: Works with CellFlo6 and Epimedium to support vascular tone and reduce inflammation.
- Liu J. J Ethnopharmacol. 1995;49(2):57–68.
- Tsai SJ et al. J Agric Food Chem. 2010;58(3):1260–1268.
- Wang Y et al. Int Immunopharmacol. 2011;11(11):1794–1799.
CitraPeak™ Glucosyl-Hesperidin (Citrus aurantium/Citrus sinensis) – 200mg
A bioavailable citrus flavonoid that improves endothelial function and nitric oxide output.
- Increases nitric oxide synthesis and enhances blood flow.
- Reduces oxidative stress and supports capillary health.
- Enhances exercise endurance via blood oxygen delivery.
- Improves thermoregulation and muscle perfusion.
- Shown to support healthy blood pressure and circulation.
Synergy: Pairs with CellFlo6 and Nitrosigine to maximize NO and antioxidant support.=
- Morand C et al. Am J Clin Nutr. 2011;93(1):73–79.
- Mas-Capdevila A et al. Nutrients. 2020;12(2):569.
- Kawabata K et al. J Nutr Sci Vitaminol (Tokyo). 2015;61(3):234–242.
Grape Seed Extract (Vitis vinifera) – std. 95% Proanthocyanidins – 200mg
A potent antioxidant compound that supports circulation, capillary integrity, and endothelial function.
- Increases NO output by enhancing eNOS activity.
- Protects blood vessels from oxidative stress.
- Improves circulation and nutrient delivery.
- Reduces post-exercise inflammation and swelling.
- Enhances performance by increasing oxygen availability.
Synergy: Pairs with Nitrosigine, Epimedium, and CellFlo6 for NO, antioxidant defense, and blood flow optimization.
- Ward NC et al. J Agric Food Chem. 2005;53(22):8618–8622.
- Terra X et al. J Agric Food Chem. 2007;55(14):5515–5521.
- Sano A et al. Hypertens Res. 2006;29(7):439–448.
EndoFlo™ (Mangifera indica, Ginkgo biloba, Pinus massoniana) – 150mg
A proprietary vasodilation blend rich in flavonoids and terpenes that enhance cerebral and peripheral blood flow.
- Increases nitric oxide availability and vascular dilation.
- Enhances mental focus and neurovascular coupling.
- Improves oxygen transport to muscles and brain.
- Reduces vascular oxidative stress.
- Promotes overall cardiovascular performance.
Synergy: Complements Nitrosigine, Grape Seed, and CitraPeak for comprehensive blood flow and cognitive synergy.
- Yoshikawa T et al. Phytother Res. 1999;13(6):494–498.
- Maclennan KM et al. Psychopharmacology (Berl). 2002;161(4):349–358.
- Müller WE et al. Pharmacopsychiatry. 1997;30(4):113–124.
Synergy Overview
Multi-pathway Vasodilation: Nitrosigine, VasoDrive AP, and CitraPeak stimulate nitric oxide, ACE inhibition, and endothelial responsiveness simultaneously.
Antioxidant Vascular Defense: Grape seed, green tea, oleanolic acid, and mango extract reduce oxidative stress to preserve vessel elasticity.
Cognitive & Circulatory Coupling: Ginkgo and Nitrosigine support both cerebral and systemic blood flow for training intensity and focus.
Foundational Support: Vitamin B3 and potassium maintain ATP production, hydration, and electrical signaling under heightened blood flow.