Vitamin D3 (as Cholecalciferol) – 125 mcg (5,000 IU) (625%)

A fat-soluble vitamin critical for calcium balance, immune modulation, and overall health.

• Supports calcium absorption and bone mineralization.
• Regulates immune function and inflammatory response.
• May promote cardiovascular health by influencing endothelial function.
• Essential for healthy muscle contraction and neuromuscular function.
• Supports mood balance and cognitive function.

Synergy: Works in tandem with Vitamin K2 to optimize calcium utilization and bone integrity while reducing vascular calcification risk.

• Holick MF. N Engl J Med. 2007;357(3):266–281.
• Pilz S et al. Clin Chim Acta. 2010;411(23–24):1570–1576.
• Zittermann A et al. Br J Nutr. 2009;101(11):1535–1544.

Vitamin K2 (as Menaquinone-7, MK-7) – 360 mcg (300%)

A highly bioavailable form of vitamin K that supports calcium transport and cardiovascular health.

• Activates osteocalcin, promoting calcium deposition into bone.
• Activates matrix Gla-protein (MGP), reducing arterial calcification.
• Supports vascular elasticity and cardiovascular resilience.
• May contribute to healthy insulin sensitivity and metabolic function.

Synergy: Complements Vitamin D3 by ensuring that absorbed calcium is directed into bone, not arterial walls.

• Schurgers LJ et al. Thromb Haemost. 2008;100(4):593–603.
• Knapen MHJ et al. Osteoporos Int. 2013;24(9):2499–2507.
• Beulens JWJ et al. Nutr Metab Cardiovasc Dis. 2009;19(7):504–510.

NovoOmega® Powdered Omega-3 Fish Oil – 4,000 mg

(Providing 720 mg EPA and 480 mg DHA; 1,200 mg total Omega-3 in triglyceride form)

A concentrated, non-GMO anchovy-derived powdered omega-3 blend standardized for EPA and DHA.

• Supports cardiovascular health by promoting healthy triglyceride levels and vascular function.
• Provides anti-inflammatory benefits supporting joint and connective tissue health.
• Promotes cognitive function and neural membrane fluidity.
• May improve mood balance and resilience against stress.
• Supports healthy vision and retinal integrity.

Synergy: Works synergistically with Vitamin D3 to modulate inflammatory pathways and enhance cardiovascular protection.

• Calder PC. Prostaglandins Leukot Essent Fatty Acids. 2012;88(2):51–58.
• Mozaffarian D et al. Circulation. 2005;111(2):157–164.
• Yurko-Mauro K et al. Alzheimer’s Dement. 2010;6(6):456–464.

Synergy Overview

Bone & Cardiovascular Balance: Vitamin D3 and Vitamin K2 synergistically regulate calcium metabolism—Vitamin D enhances calcium absorption, while Vitamin K2 directs calcium into bone and prevents arterial deposition.

Inflammation & Vascular Support: Omega-3 fatty acids and Vitamin D3 work together to downregulate pro-inflammatory cytokines, supporting vascular health and balanced immune response.

Cognitive & Mood Health: Omega-3 EPA/DHA contribute to neuronal membrane integrity, while Vitamin D3 supports neurotransmitter balance, creating a foundation for cognitive performance and emotional well-being.

Lipid Metabolism & Heart Health: Omega-3 supplementation reduces serum triglycerides and supports HDL balance, further reinforced by Vitamin K2’s role in vascular elasticity.

Absorption & Bioavailability: The powdered triglyceride form of Omega-3 ensures efficient absorption, especially when paired with the fat-soluble nature of Vitamins D3 and K2.