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Cissus (Cissus quadrangularis) Extract (Stem) (std. min. 40% Ketosterones) – 1,000mg

A botanical extract traditionally used in Ayurvedic medicine for bone and joint health.

• May support bone healing and density by stimulating osteoblast proliferation
• Can help reduce joint pain and inflammation
• Promotes collagen synthesis, beneficial for ligaments and tendons
• May support metabolic health and healthy weight management
• Contains antioxidants that mitigate oxidative damage in musculoskeletal tissues

Synergy: Pairs effectively with Chicken Collagen Type II and Hyaluronic Acid to support cartilage integrity and joint lubrication.

• Chopra A et al. Evid Based Complement Alternat Med. 2012;2012:582792.
• Oben J et al. Lipids Health Dis. 2006;5:24.
• Stohs SJ et al. J Diet Suppl. 2012;9(3):180–191.

 

Palmitoylethanolamide (PEA) – 600mg

A naturally occurring fatty acid amide with analgesic and anti-inflammatory properties.

• Supports reduction of chronic pain and neuropathic discomfort
• Modulates inflammatory pathways (mast cell degranulation)
• Promotes endocannabinoid system balance without psychoactivity
• May improve nerve function and recovery
• Helps maintain homeostasis under stress

Synergy: Combines well with Boswellia serrata and Curcumin to provide a comprehensive anti-inflammatory effect.

• Skaper SD et al. Pharmacol Res. 2014;86:32–41.
• Petrosino S et al. Biochimie. 2010;92(6):724–727.
• Paladini A et al. Pain Physician. 2016;19(2):11–24.

 

Ayuflex® Chebulic Myrobalan Extract (Terminalia chebula) (Fruit) – 500mg

A standardized herbal extract rich in tannins and polyphenols traditionally used for joint health.

• Reduces symptoms of osteoarthritis (pain, stiffness)
• Protects cartilage by reducing oxidative stress
• Supports connective tissue resilience
• May improve mobility and flexibility
• Provides antioxidant support for musculoskeletal tissues

Synergy: Works synergistically with Cissus and Curcumin for cartilage protection and inflammation reduction.

• Shah RV et al. J Ayurveda Integr Med. 2020;11(1):52–58.
• Ghosal S et al. Planta Med. 1996;62(4):316–320.
• Patel DK et al. Asian Pac J Trop Biomed. 2012;2(6):S2145–S2149.

 

Curcumin from Turmeric (Curcuma longa) (std. min. 95% Curcuminoids) – 500mg

A potent anti-inflammatory compound extracted from turmeric root.

• Inhibits NF-κB and COX-2 pathways to reduce inflammation
• Provides antioxidant protection to joints
• Supports cartilage preservation and collagen synthesis
• May alleviate symptoms of arthritis
• Enhances recovery from exercise-related soreness

Synergy: BioPerine black pepper dramatically improves curcumin bioavailability; also complements Boswellia’s inflammatory pathway modulation.

• Hewlings SJ, Kalman DS. Foods. 2017;6(10):92.
• Gupta SC et al. Biotechnol Adv. 2013;31(6):1053–1064.
• Chainani-Wu N. J Altern Complement Med. 2003;9(1):161–168.

 

PARACTIN® Andrographis Paniculata Extract (Patented Bioactive 14-Neo-Andro Compound) – 300mg

A patented extract standardized for andrographolide content with immune-modulating and anti-inflammatory effects.

• Reduces inflammatory cytokines (TNF-α, IL-1β, IL-6)
• Supports joint comfort and mobility
• Promotes healthy immune balance
• May improve resilience during stress and illness
• Provides antioxidant defense

Synergy: Acts in concert with Curcumin and Boswellia for inflammation control and immune support.

• Burgos RA et al. Phytother Res. 2009;23(7):919–924.
• Puri A et al. J Ethnopharmacol. 1993;42(2):101–109.
• Coon JT, Ernst E. Br J Gen Pract. 2004;54(503):911–914.

 

Chicken Collagen Type II – 250mg

Undenatured type II collagen derived from chicken cartilage.

• Supports cartilage regeneration and structure
• May reduce pain and stiffness in osteoarthritis
• Modulates immune responses (oral tolerance)
• Enhances joint comfort and flexibility
• Supports overall connective tissue health

Synergy: Enhanced by Hyaluronic Acid and Cissus for comprehensive cartilage and synovial support.

• Lugo JP et al. Int J Med Sci. 2016;13(4):285–292.
• Crowley DC et al. Int J Med Sci. 2009;6(6):312–321.
• Trentham DE et al. Science. 1993;261(5129):1727–1730.
  
  

Hyaluronic Acid (from Sodium Hyaluronate) – 200mg

A polysaccharide critical for joint lubrication and shock absorption.

• Increases synovial fluid viscosity and cushioning
• Reduces friction and wear in joints
• May alleviate joint pain and stiffness
• Supports skin and connective tissue hydration
• Facilitates cartilage nutrient transport

Synergy: Works synergistically with Chicken Collagen and Cissus to protect and nourish joint structures.

• Balazs EA, Denlinger JL. J Rheumatol Suppl. 1989;15:3–9.
• Bannuru RR et al. Ann Intern Med. 2009;151(3):180–190.
• Henrotin Y et al. BMC Musculoskelet Disord. 2010;11:226.

 

AprèsFlex® Boswellia Serrata Extract (std. min. 20% AKBA) – 100mg

A next-generation Boswellia gum resin extract standardized for AKBA, a potent 5-LOX inhibitor.

• Reduces joint inflammation and pain
• Inhibits leukotriene production to protect cartilage
• Promotes comfort and mobility
• Provides antioxidant support
• May slow cartilage degradation

Synergy: Complements Curcumin and PEA by targeting different inflammatory pathways (COX-2, LOX, mast cell).

• Sengupta K et al. Int J Med Sci. 2010;7(6):366–377.
• Umar S et al. J Ethnopharmacol. 2014;157:206–216.
• Sharma ML et al. Agents Actions. 1983;13(5-6):541–545.

 

AstraGin® (Panax Notoginseng + Astragalus membranaceus Extracts) – 50mg

A patented blend that enhances nutrient absorption and bioavailability.

• Improves uptake of amino acids, vitamins, and botanicals
• Supports gut barrier function and digestive health
• May enhance immune response
• Contributes to better efficacy of active ingredients
• Promotes energy metabolism

Synergy: Boosts absorption of Curcumin, Boswellia, Cissus, and other phytonutrients.

• He Z et al. Food Chem Toxicol. 2012;50(7):2336–2341.
• Johnson JJ. J Funct Foods. 2015;17:810–819.
• Li Y et al. J Agric Food Chem. 2011;59(9):4519–4526.

 

Q-Actin® Gherkin Cucumber Extract (std. to NLT 1% Ido-BR1 Iminosugar) – 20mg

A standardized cucumber extract shown to reduce joint discomfort.

• Helps decrease joint pain and stiffness
• Provides antioxidant protection
• May support cartilage health
• Promotes flexibility and comfort
• Contributes to musculoskeletal recovery

Synergy: Complements Chicken Collagen and Boswellia for a holistic approach to joint relief.

• Rokkappanavar KK et al. J Med Food. 2020;23(2):208–216.
• Nair S et al. Int J Pharm Sci Res. 2017;8(9):3767–3773.
• Rokkappanavar KK et al. J Diet Suppl. 2021;18(3):315–325.

 

BioPerine® Black Pepper Extract (std. min. 95% Piperine) – 5mg

A patented black pepper extract that enhances nutrient absorption.

• Significantly improves bioavailability of Curcumin and other compounds
• Stimulates digestive enzyme secretion
• Provides antioxidant benefits
• May support metabolic health
• Contributes to thermogenic activity

Synergy: Increases absorption of Curcumin, Boswellia, Cissus, and PEA for maximized efficacy.

• Shoba G et al. Planta Med. 1998;64(4):353–356.
• Srinivasan K. Crit Rev Food Sci Nutr. 2007;47(8):735–748.
• Lambert JD et al. Mol Nutr Food Res. 2007;51(5):538–545.

 

Synergy Overview

Inflammation Control: Curcumin, Boswellia, PEA, PARACTIN®, and Ayuflex® target complementary inflammatory pathways (NF-κB, COX-2, LOX, cytokines), creating a powerful anti-inflammatory matrix.

Cartilage & Joint Protection: Cissus, Chicken Collagen, Hyaluronic Acid, and Q-Actin® reinforce cartilage integrity, synovial lubrication, and flexibility.

Bioavailability & Absorption: AstraGin® and BioPerine® increase the uptake of nutrients and actives, ensuring maximum utilization.

Oxidative Stress Defense: Curcumin, Boswellia, Ayuflex®, and Q-Actin® contribute antioxidant protection for joint tissues.

Immune Modulation & Recovery: PARACTIN®, PEA, and AstraGin® support balanced immune activity and faster musculoskeletal recovery.