BRAIN: NOOTROPIC COMPLEX
BRAIN: NOOTROPIC COMPLEX
BRAIN: NOOTROPIC COMPLEX
BRAIN: NOOTROPIC COMPLEX
BRAIN: NOOTROPIC COMPLEX
BRAIN: NOOTROPIC COMPLEX
BRAIN: NOOTROPIC COMPLEX
BRAIN: NOOTROPIC COMPLEX

BRAIN: NOOTROPIC COMPLEX

$49.99
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BRAIN: NOOTROPIC COMPLEX

Focus • Creativity • Memory

BRAIN is a comprehensive cognitive enhancement and brain health supplement designed to support focus, memory, energy metabolism, and long-term neural resilience.

It combines a full spectrum of B-vitamins with clinically studied botanicals, nootropics, and adaptogens like Lion’s Mane, Mucuna, Ginkgo, Gotu Kola, and Salidroside, along with choline donors for neurotransmission and enzyme inhibitors for long lasting effects.

The result is a synergistic blend that fuels neurotransmitter production, protects brain cells from oxidative stress, and promotes both immediate cognitive performance and long-term neurological health.

 

Key Benefits:

  • Supports focus, clarity, and working memory
  • Enhances neurotransmitter production and signaling
  • Promotes brain-derived neurotrophic factor (BDNF) and neuroplasticity
  • Reduces mental fatigue while supporting stress resilience
  • Improves overall brain energy metabolism and cellular protection
  • Supports creative thinking and mental flexibility for complex problem-solving
  • Promotes smoother cognitive processing for task switching and multitasking
  • Helps maintain calm alertness during high-pressure work or training environments
  • Encourages long-term neuronal health through antioxidant and adaptogenic support
  • Supports dopamine and acetylcholine pathways for enhanced motivation and learning
  • Enhances cognitive stamina for sustained productivity and deep-work sessions

 

 

Vitamin B1 (Thiamin mononitrate) — 1.2 mg

Essential cofactor for carbohydrate metabolism and mitochondrial ATP production.

  • Supports neuronal glucose metabolism and energy delivery
  • Contributes to nerve conduction and focus
  • Helps reduce fatigue in demanding tasks

Synergy: With B2/B3/B5 for mitochondrial energy and with CDP-Choline + UMP for acetylcholine synthesis.

  • Kennedy DO. Nutrients. 2016;8:68.
  • Gibson GE et al. Neurochem Int. 2016;93:73–81.
  • Balk EM et al. Evid Rep Technol Assess. 2006;(147).

 

 

Vitamin B2 (Riboflavin-5-phosphate) — 1.3 mg

Coenzyme for FAD/FMN in redox metabolism and antioxidant cycling.

  • Supports mitochondrial ATP output
  • Aids glutathione recycling
  • Helps manage homocysteine with B6/B12/Folate

Synergy: Complements B3 in ETC energy flux; enhances antioxidant action with Black Cumin and Salidroside.

  • Powers HJ. Am J Clin Nutr. 2003;77:1352–1360.
  • Ashoori M, Saedisomeolia A. J Res Med Sci. 2014;19:979–986.
  • Kennedy DO. Nutrients. 2016;8:68.

 

 

Vitamin B3 (Niacinamide) — 16 mg NE

NAD+/NADP+ precursor, critical for cellular energy and DNA repair.

  • Enhances brain energy metabolism
  • Activates sirtuin/repair pathways for neuroprotection
  • Supports mood and stress resilience

Synergy: With UMP and CDP-Choline for membrane health; with Lion’s Mane and Salidroside for neuroplasticity.

  • Fang EF et al. Trends Mol Med. 2017;23:899–916.
  • Bogan KL, Brenner C. Annu Rev Nutr. 2008;28:115–130.
  • Kennedy DO. Nutrients. 2016;8:68.

 

 

Vitamin B6 (Pyridoxal-5-phosphate) — 1.7 mg

Active coenzyme for amino acid decarboxylases, essential for neurotransmitter synthesis.

  • Supports dopamine, serotonin, and GABA formation
  • Helps regulate homocysteine metabolism
  • Improves mood and stress adaptation

Synergy: Converts Mucuna (L-DOPA) to dopamine; balances dopaminergic and cholinergic tone with CDP-Choline/UMP.

  • Dakshinamurti K. Ann NY Acad Sci. 1990;585:128–144.
  • Hvas AM, Nexo E. Am J Clin Nutr. 2006;83:842–846.
  • Kennedy DO. Nutrients. 2016;8:68.

 

 

Folate (5-MTHF) — 400 mcg DFE

Active methylated folate form crossing the BBB.

  • Supports neurotransmitter and phospholipid methylation
  • Maintains vascular and cognitive health
  • Enhances mood and cognition in low-folate states

Synergy: With B12 and B6 for methylation; with CDP-Choline and UMP for membrane synthesis.

  • Stover PJ. Annu Rev Nutr. 2004;24:299–326.
  • Mischoulon D, Fava M. CNS Spectr. 2002;7:187–190.
  • Reynolds E. Lancet Neurol. 2006;5:949–960.

 

 

Vitamin B12 (Methylcobalamin) — 2.4 mcg

 Active B12 essential for methylation and myelin.

  • Supports nerve conduction and myelination
  • Aids cognition via homocysteine regulation
  • Enhances cellular energy metabolism

Synergy: With folate + B6 for one-carbon metabolism; with choline/UMP for phospholipid support.

  • O’Leary F, Samman S. Nutrients. 2010;2:299–316.
  • Smith AD, Refsum H. J Intern Med. 2021;290:964–979.
  • Moore E et al. Cochrane Database Syst Rev. 2018;CD004514.

 

 

Pantothenic Acid (Vitamin B5) — 5 mg

Precursor to coenzyme A for acetyl-CoA and acetylcholine.

  • Supports acetylcholine synthesis for learning and focus
  • Aids fatty acid metabolism and energy release
  • Contributes to adrenal stress response

Synergy: With CDP-Choline and UMP for acetylcholine production; with adaptogens for balanced stress response.

  • Leonardi R et al. Prog Lipid Res. 2005;44:125–153.
  • de Villiers CP et al. Chem Rev. 2012;112:1–42.
  • Kennedy DO. Nutrients. 2016;8:68.

 

 

Lion’s Mane (Hericium erinaceus; fruiting body) — 1,000 mg

Mushroom rich in hericenones and erinacines that stimulate NGF/BDNF.

  • Promotes neurogenesis and synaptic plasticity
  • Supports memory and cognition
  • Improves mood and reduces anxiety in some trials

Synergy: With CDP-Choline + UMP for synaptic repair, and with Ginkgo + Gotu Kola + Salidroside for neurovascular and neurotrophic synergy.

  • Mori K et al. Phytother Res. 2009;23:367–372.
  • Kawagishi H et al. Int J Med Mushrooms. 2008;10:1–7.
  • Saitsu Y et al. Int J Mol Sci. 2019;20:882.

 

 

Velvet Bean (Mucuna pruriens; 98% L-DOPA) — 750 mg

Plant source of L-DOPA, the direct dopamine precursor.

  • Supports motivation, drive, and reward pathway signaling
  • Improves mood and resilience under stress
  • Provides antioxidant neuroprotection

Synergy: With P5P for conversion to dopamine; with Black Cumin (MAO inhibition) to preserve dopamine; with CDP-Choline/UMP to balance dopaminergic and cholinergic tone.

  • Katzenschlager R et al. J Neurol Neurosurg Psychiatry. 2004;75:1672–1677.
  • Manyam BV et al. Phytother Res. 2004;18:706–712.
  • Misra L, Wagner H. Phytochemistry. 2007;68:197–202.

 

 

Black Cumin (Nigella sativa; 10:1 extract) — 400 mg

Seed extract with thymoquinone and alkaloids that provide antioxidant and neuromodulatory benefits.

  • Improves memory and cognition in human studies
  • Provides antioxidant and anti-inflammatory protection
  • Supports mood and resilience under stress
  • Inhibits monoamine oxidase (MAO), prolonging dopamine, serotonin, and norepinephrine action → enhances motivation, mood stability, and mental clarity.

Synergy: With Mucuna (L-DOPA) and B6 to sustain dopamine levels; with Ginkgo + Gotu Kola for neurotransmission and perfusion; with Lion’s Mane for neuroplasticity.

  • Hosseini MS et al. Phytother Res. 2013;27:1746–1750.
  • Bin Sayeed MS et al. J Ethnopharmacol. 2013;148:780–787.
  • Perveen T et al. Phytomedicine. 2014;21:232–239.

 

 

Ginkgo biloba (leaf 4:1) — 360 mg

Extract rich in flavone glycosides and terpenoids that enhance cerebral circulation.

  • Supports memory and processing speed
  • Improves cerebral blood flow and neurovascular function
  • Provides antioxidant protection to neurons

Synergy: With CDP-Choline/UMP for cognitive signaling; with Gotu Kola and Lion’s Mane for neuroplasticity; with Black Cumin + Salidroside for oxidative balance.

  • Weinmann S et al. BMC Geriatr. 2010;10:14.
  • Hashiguchi M et al. Curr Med Res Opin. 2015;31:601–613.
  • Tan MS et al. J Alzheimers Dis. 2015;43:589–603.

 

 

Galangal (Alpinia galanga; root 5:1) — 300 mg

Rhizome containing 1′-acetoxychavicol acetate and flavonoids.

  • Supports mental clarity and alertness
  • Provides anti-inflammatory and antioxidant neuroprotection
  • Aids digestive comfort and adaptogenic balance

Synergy: With Black Cumin and Salidroside to reduce neuroinflammation; supports perfusion and neurotransmission synergy with Ginkgo and Gotu Kola.

  • Yoshida T et al. J Agric Food Chem. 2008;56:6067–6072.
  • Akbik D et al. Phytother Res. 2014;28:475–481.
  • Rujjanawate C et al. J Med Assoc Thai. 2005;88:S315–S321.

 

 

Gotu Kola (Centella asiatica; 4:1) — 250 mg

Ayurvedic herb with triterpenoids that support neuroplasticity and microcirculation.

  • Supports memory, attention, and calm focus
  • Promotes BDNF-driven neurogenesis
  • Improves microvascular integrity and cerebral perfusion

Synergy: With Ginkgo for vascular support; with Lion’s Mane for neuroplasticity; with Black Cumin + Salidroside for neurotransmitter balance and oxidative protection.

  • Kumar A, Gupta A. J Ethnopharmacol. 2002;79:253–260.
  • Wattanathorn J et al. J Ethnopharmacol. 2008;116:325–332.
  • Brinkhaus B et al. Phytomedicine. 2000;7:427–448.

 

 

Citicoline (CDP-Choline; from citicoline sodium) — 250 mg

Source of choline + cytidine, supporting phospholipid synthesis and acetylcholine.

  • Enhances attention, focus, and psychomotor speed
  • Supports neuronal membrane integrity and repair
  • Increases brain phosphocreatine/ATP (MRS evidence)

Synergy: With UMP for Kennedy pathway phospholipid synthesis; with B5 for acetylcholine; with Ginkgo + Lion’s Mane for synaptic resilience.

  • Secades JJ. CNS Drugs. 2016;30:185–206.
  • McGlade E et al. Int J Neuropsychopharmacol. 2015;18:pyu107.
  • Adibhatla RM, Hatcher JF. Brain Res. 2002;947:190–198.

 

 

Uridine-5′-monophosphate — 250 mg

Pyrimidine nucleotide supporting membrane synthesis and synaptic growth.

  • Promotes synaptogenesis and dendritic spine density
  • Supports phospholipid turnover and neural repair
  • Enhances motivation and mood (preclinical + human synergy data)

Synergy: With CDP-Choline for Kennedy pathway; with Lion’s Mane for plasticity; with Black Cumin (MAO inhibition) to pair structural growth with neurotransmitter activity.

  • Wurtman RJ et al. Brain Res Bull. 2006;69:401–406.
  • Cansev M et al. Neuroscience. 2008;152:597–604.
  • Soininen H et al. Alzheimer’s Dement. 2017;13:284–294.

 

 

CogniUP® (Huperzia serrata, Convolvulus pluricaulis, Celastrus paniculatus) — 100 mg

Multi-herbal blend: Huperzia (huperzine A, AChE inhibitor), Shankhpushpi (calming memory herb), Celastrus (“Intellect tree”).

  • Supports acetylcholine levels and memory retention
  • Enhances learning and working memory
  • Provides antioxidant and anti-stress activity

Synergy: Works with CDP-Choline + UMP for cholinergic support; balanced by adaptogens (Gotu Kola, Lion’s Mane, Salidroside) to sharpen cognition without overstimulation.

  • Xu SS et al. Acta Pharmacol Sin. 1995;16:391–395.
  • Singh RH, Udupa KN. J Res Ayurveda Siddha. 1972;1:133–148.
  • Rao VR et al. Phytother Res. 2007;21:1001–1006.

 

 

Salidroside (from Salidropure®) — 20 mg

Bioactive from Rhodiola rosea with adaptogenic and mitochondrial effects.

  • Enhances mental performance and resilience under fatigue
  • Provides neuroprotection via antioxidant and anti-inflammatory pathways
  • Supports dopamine and serotonin balance

Synergy: With Mucuna and Black Cumin for neurotransmitter tone; with Lion’s Mane and Gotu Kola for neuroplastic resilience; with Galangal for antioxidant/anti-stress synergy.

  • Panossian A et al. Phytomedicine. 2010;17:481–493.
  • Chen QG et al. Neurochem Int. 2009;54:421–428.
  • Zhu Y et al. Phytother Res. 2011;25:463–471.

 

 

BioPerine® (Piper nigrum extract; ≥95% piperine) — 5 mg

Black pepper extract enhancing bioavailability of nutrients.

  • Increases absorption of bioactives (choline, herbs, vitamins)
  • Provides mild antioxidant and thermogenic effects
  • Enhances overall formula efficacy

Synergy: Boosts uptake of B-complex, adaptogens, and nootropics including Lion’s Mane, Salidroside, and Black Cumin.

  • Shoba G et al. Planta Med. 1998;64:353–356.
  • Srinivasan K. Crit Rev Food Sci Nutr. 2007;47:735–748.
  • Lambert JD et al. J Nutr. 2004;134:1948–1952.

 

 

Synergy Overview

Neurotransmitter Balance: Mucuna (dopamine precursor), Black Cumin (MAO inhibition), and P5P (dopamine synthesis) work together to elevate and sustain motivation and mood.

Cholinergic & Synaptic Support: CDP-Choline, UMP, B5, and CogniUP enhance acetylcholine levels and membrane synthesis, reinforced by Lion’s Mane neurotrophic effects.

Neuroplasticity & Growth: Lion’s Mane, Gotu Kola, and UMP promote BDNF and neurite outgrowth, building structural plasticity that synergizes with neurotransmitter tone.

Circulation & Perfusion: Ginkgo and Gotu Kola improve cerebral blood flow, amplifying delivery of oxygen and nutrients for higher cognitive output.

Stress & Resilience: Salidroside, Galangal, and Black Cumin reduce oxidative and inflammatory stress, protecting neurons during high-demand activity.

Absorption & Potentiation: BioPerine® ensures maximum utilization of both botanical and nutrient actives.

 

FAQ

Q: What has changed from the previous version?

A: The new formula has been rebuilt into a fully stacked, multi-pathway nootropic. It moves away from a smaller 6-ingredient blend and now features a much broader profile, with vitamins, neurotransmitter precursors, adaptogens, and cholinergics all working together.

 

 

Q: What are the biggest upgrades or additions?

A:

  • B-Complex (B1, B2, B3, B6, Folate, B12, Pantothenic Acid): Foundational cofactors for neurotransmitter synthesis and brain energy.
  • Mucuna pruriens (L-DOPA): Direct dopamine precursor to support motivation and drive.
  • Black Cumin (MAO inhibition): Helps preserve neurotransmitters like dopamine and serotonin.
  • Galangal Root: Provides anti-inflammatory and cognitive support.
  • CDP-Choline + Uridine: Dual precursors for acetylcholine and membrane repair (Kennedy pathway).
  • Gotu Kola + Salidroside: Neurotrophic adaptogens for BDNF and neuroprotection.
  • BioPerine®: Improves absorption of the full formula.

This represents a major expansion in scope, from a traditional herbal nootropic to a clinical-style brain optimization stack.

 

 

Q: Which ingredients stayed the same?

A: Both formulas include:

  • Lion’s Mane Mushroom (1,000 mg) – cornerstone for neurogenesis.
  • Celastrus (Intellect Tree) – traditional Ayurvedic nootropic.
  • Ginkgo biloba – for cerebral circulation and memory.

 

 

Q: What was removed and why?

A:

  • Alpha-GPC: Replaced by CDP-Choline + Uridine, which provide more comprehensive cholinergic + structural support.
  • Bacopa: Removed in favor of Gotu Kola and Salidroside, which provide similar memory/adaptogen effects but with broader neuroplasticity synergy.
  • Sabroxy® (Indian Trumpet Tree): Removed; the new design emphasizes dopaminergic tone (Mucuna + Black Cumin + Salidroside) instead of high oroxylin A dosing.

These changes shift the formula toward neurotransmitter balance + plasticity rather than relying solely on herbal memory tonics.

 

 

Q: How do I best use this new formula?

A:

  • Take 6 capsules with food for best absorption. We recommend 6 capsules daily Monday-Friday or 4 capsules daily for the entire month.
  • Timing: Morning or early afternoon use is recommended (dopamine + acetylcholine support).
  • Stacking: Can be paired with coffee, energy drinks, or stimulant-based pre-workouts or focus aids; this provides the foundation for neurotransmitter production and long-term brain health.
  • Consistency: Best results appear with daily use over weeks, not just acute doses.

 

 

Q: Who should take this?

A:

  • Ideal for:
    • Professionals and students wanting focus, memory, and productivity support
    • Athletes looking for motivation, drive, and neuroprotection
    • Anyone interested in long-term brain health and resilience
  • Not ideal for:
    • Individuals extremely sensitive to dopaminergic activity (due to Mucuna + MAO inhibition)
    • Pregnant or nursing women (due to limited safety data on some botanicals)